Clinical and genetic predictors of paclitaxel neurotoxicity based on patient- versus clinician-reported incidence and severity of neurotoxicity in the ICON7 trial.
Identifieur interne : 000F88 ( Main/Exploration ); précédent : 000F87; suivant : 000F89Clinical and genetic predictors of paclitaxel neurotoxicity based on patient- versus clinician-reported incidence and severity of neurotoxicity in the ICON7 trial.
Auteurs : S B Park [Australie] ; J B Kwok [Australie] ; R. Asher [Australie] ; C K Lee [Australie] ; P. Beale [Australie] ; F. Selle [France] ; M. FriedlanderSource :
- Annals of oncology : official journal of the European Society for Medical Oncology [ 1569-8041 ] ; 2017.
Abstract
Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting toxicity of paclitaxel, with no reliable method to identify at-risk patients. We investigated the incidence and risk factors including genetic polymorphisms associated with the development of CIPN based on clinician and patient reporting of neuropathic symptoms.
DOI: 10.1093/annonc/mdx491
PubMed: 29117336
Affiliations:
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<front><div type="abstract" xml:lang="en">Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting toxicity of paclitaxel, with no reliable method to identify at-risk patients. We investigated the incidence and risk factors including genetic polymorphisms associated with the development of CIPN based on clinician and patient reporting of neuropathic symptoms.</div>
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