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Clinical and genetic predictors of paclitaxel neurotoxicity based on patient- versus clinician-reported incidence and severity of neurotoxicity in the ICON7 trial.

Identifieur interne : 000F88 ( Main/Exploration ); précédent : 000F87; suivant : 000F89

Clinical and genetic predictors of paclitaxel neurotoxicity based on patient- versus clinician-reported incidence and severity of neurotoxicity in the ICON7 trial.

Auteurs : S B Park [Australie] ; J B Kwok [Australie] ; R. Asher [Australie] ; C K Lee [Australie] ; P. Beale [Australie] ; F. Selle [France] ; M. Friedlander

Source :

RBID : pubmed:29117336

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting toxicity of paclitaxel, with no reliable method to identify at-risk patients. We investigated the incidence and risk factors including genetic polymorphisms associated with the development of CIPN based on clinician and patient reporting of neuropathic symptoms.

DOI: 10.1093/annonc/mdx491
PubMed: 29117336


Affiliations:


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Le document en format XML

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